PATHOPHYSIOLOGY OF DENGUE
Presence
of vector w/ Dengue virus
 |
Enters
the body of the host
 |
Is
distributed through the blood stream
 |
Virus may directly affect the liver virus invades host cell triggers
immune response/
Antibody production
Production of clotting factors/
Prothrombin production of properdin and C1,4,2,3
 |
Immune adherence to
platelet activation of kallikrein-kinin strong immune complex
system reaction |
platelet injury
kinin release
production
of histamine |
|
Reticulo-endothelial cells
destroys damaged
platelet
Vascular permeability
(+
tourniquet test)
Thrombocytopenia |
Extravasation of fluids
Bleeding Hypotension
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