Thursday, March 14, 2013


PATHOPHYSIOLOGY OF DENGUE



Presence of vector w/ Dengue virus
 


Enters the body of the host
 


Is distributed through the blood stream
 

                                                                                                                            
                                                                                                                                   
Virus may directly affect the liver               virus invades host cell                       triggers immune response/
                                                                                                                      Antibody production
           
       Production of clotting factors/
                      Prothrombin                       production of properdin and C1,4,2,3
 

                                   
                                                                                                          
       Immune adherence to platelet              activation of kallikrein-kinin                    strong immune complex
                                                                               system                                                    reaction  
 

                 platelet injury          
                                                                           kinin release                                      production of histamine
 

          Reticulo-endothelial cells
         destroys damaged platelet
                                                                                     Vascular permeability
                                                                       (+ tourniquet test)
                Thrombocytopenia
 

                                                                                                               Extravasation of fluids
                       

                         Bleeding                                                                           Hypotension

1 comment:

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