PATHOPHYSIOLOGY OF DENGUE
Presence
of vector w/ Dengue virus
Enters
the body of the host
Is
distributed through the blood stream
Virus may directly affect the liver virus invades host cell triggers
immune response/
Antibody production
Production of clotting factors/
Prothrombin production of properdin and C1,4,2,3
Immune adherence to
platelet activation of kallikrein-kinin strong immune complex
system reaction
platelet injury
kinin release
production
of histamine
Reticulo-endothelial cells
destroys damaged
platelet
Vascular permeability
(+
tourniquet test)
Thrombocytopenia
Extravasation of fluids
Bleeding Hypotension
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